Perspectives of targeted mass spectrometry for protein biomarker verification
نویسندگان
چکیده
منابع مشابه
Protein quantitation through targeted mass spectrometry: the way out of biomarker purgatory?
The enormous potential of biomarkers to revolutionize clinical practice and improve patient care has been well documented (1, 2 ). Molecular-based diagnostic and prognostic tests, particularly those aimed at protein analytes, could be used to detect disease earlier, enabling treatment to start sooner and possibly cure rather than to merely delay further injury or death. These tools could also b...
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The enormous potential of biomarkers to revolutionize clinical practice and improve patient care has been well documented (1, 2 ). Molecular-based diagnostic and prognostic tests, particularly those aimed at protein analytes, could be used to detect disease earlier, enabling treatment to start sooner and possibly cure rather than to merely delay further injury or death. These tools could also b...
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In medicine, there is an urgent need for protein biomarkers in a range of applications that includes diagnostics, disease stratification, and therapeutic decisions. One of the main technologies to address this need is MS, used for protein biomarker discovery and, increasingly, also for protein biomarker validation. Currently, data-dependent analysis (also referred to as shotgun proteomics) and ...
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It has really been only in the last 10 years that mass spectrometry (MS) has had a truly important (but still small) impact on biomedical research. Much of this impact can be attributed to proteomics and its more basic applications. Early biomedical applications have included a number of efforts aimed at developing new biomarkers; however, the success of these endeavors to date have been quite ...
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The natural history of disease is usually a story of progression from an early stage in which homeostasis is only mildly perturbed and easily restored, through a series of increasingly involved stages characterized by a steady increase in the extent and impact of pathological change. Eventually the disease process becomes irreversible, and treatment is ameliorative at best. One of the major goa...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2009
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2009.09.014